Ultrastructural immunolocalization of bone sialoprotein in guinea-pig osteoarthritis
نویسندگان
چکیده
منابع مشابه
Guinea Pig Model of Osteoarthritis
Objective. To analyze the in vivo compartmental expression of collagenases 1 and 3 (MMP-1 and MMP13) in the Hartley guinea pig model of spontaneously occurring osteoarthritis (OA) for the purpose of elucidating their roles in the pathogenesis of OA. Methods. Competitive reverse transcriptionpolymerase chain reaction (RT-PCR) and immunohistochemistry quantification of messenger RNA (mRNA) and pr...
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Aquaporin CHIP (AQP-CHIP) is a water channel protein previously identified in red blood cells and water transporting epithelia. The inner ear is an organ of hearing and balance whose normal function depends critically on maintenance of fluid homeostasis. In this study, AQP-CHIP, or a close homologue, was found in specific cells of the inner ear, as assessed by immunocytochemistry with the use o...
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Changes in osteoarthritis joint appear in the articular cartilage, synovium and in subchondral bone. It is necessary to find, apart from markers of cartilage destruction, a sensitive and specific biochemical marker which would reflect the metabolism as well as degradation of subchondral bone. Bone sialoprotein is mostly synthesized in osseous tissue found directly under the surface of joint car...
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The minimal K' channel protein (minK, also called ISK) is structurally dissimilar to other cloned voltage-gated ion channels. minK is a 15-kD polypeptide with only one potential transmembrane helix. Published data suggest that the current associated with minK expression in Xenopus oocytes may be related to the slow cardiac delayed rectifier K' current (IK). However, the fact that minK expressio...
متن کاملMorphometrical Study of the Temporal Bone and Auditory Ossicles in Guinea Pig
In this research, anatomical descriptions of the structure of the temporal bone and auditory ossicles have been performed based on dissection of ten guinea pigs. The results showed that, in guinea pig temporal bone was similar to other animals and had three parts; squamous, tympanic and petrous .The tympanic part was much better developed and consisted of oval shaped tympanic bulla with many re...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 1997
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(97)80043-x